Cytochrome P450 enzymes
Topic: Pharmacology
A family of enzymes, mainly in the liver and gut, that metabolize many drugs (e.g., CYP3A4, CYP2D6). Enzyme inducers (e.g., rifampin, carbamazepine, St. John's wort) speed metabolism and can make other drugs fail; inhibitors (e.g., clarithromycin, fluconazole, grapefruit juice) slow it and can push other drugs to toxic levels. Genetic differences make some people fast or slow metabolizers. This underlies many serious interactions, for example with warfarin. Check every new drug, supplement and herbal product against the client's medication list, and report interactions.
- Also known as:
- CYP450, Enzyme induction, Enzyme inhibition
- In Turkish:
- Sitokrom P450 enzimleri
What does Cytochrome P450 enzymes mean?
Cytochrome P450 enzymes is part of the Pharmacology topic in nursing. Students meet it in class, on clinical placements and while preparing for exams.
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